M.Sc. Bio-Chemistry (PU-CET P.G) 2017 Panjab University Entrance Exam With Answers

LDL binds with cell surface receptor and gets internalized via clathrin-mediated endocytosis. This process helps in maintaining the cholesterol-LDL level in the plasma. However, in a disease known as familial hypercholesterolemia (FH), very high levels of plasma cholesterol is found. This could be due to mutation in which one of the following genes in FH patients?