A protein in 100 mM KCl solution was heated and the observed Tm (midpoint of unfolding) was 60oC. When the same protein solution in 500 mM KCl was heated, the observed Tm was 65oC. What is the most probable reason for this increase in Tm ?

M.Sc. Bio-Physics (PU-CET P.G) 2016 Panjab University Entrance Exam With Answers

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21.

A: Hydrogen bonding is increased

B: Hydrophobic interaction is decreased and electrostatic repulsion is increased

C: Hydrophobic interaction is increased and electrostatic repulsion is decreased

D: van der Waals interaction is increased

The answer is: B

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